Publications

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First Author

Risk Prediction ● Polygenic Risk Score ● Genetic Epidemiology ● Academic Writing ● Heritability ● Genetic Epidemiology ● Causal Inference ● Social Epidemiology ● Polygenic Risk Score ● Research Ethics ● Polygenic Risk Score ● Genetic Epidemiology ● Science Communication ● GWAS ● GWAS ● Causal Inference ● Heritability ● Research Funding ● Genetic Epidemiology ● Literature Management ● LD Score Regression ● Research Methods ● Announcement ● Risk Prediction ● Tohoku Medical Megabank Organization ● Preeclampsia ● GWAS ● Social Isolation ● Mendelian Randomization ● Perinatal Period ● Research Methods ● Risk Prediction ● Polygenic Risk Score ● Genetic Epidemiology ● Academic Writing ● Heritability ● Genetic Epidemiology ● Causal Inference ● Social Epidemiology ● Polygenic Risk Score ● Research Ethics ● Polygenic Risk Score ● Genetic Epidemiology ● Science Communication ● GWAS ● GWAS ● Causal Inference ● Heritability ● Research Funding ● Genetic Epidemiology ● Literature Management ● LD Score Regression ● Research Methods ● Announcement ● Risk Prediction ● Tohoku Medical Megabank Organization ● Preeclampsia ● GWAS ● Social Isolation ● Mendelian Randomization ● Perinatal Period ● Research Methods ●

Topic

2026

3
First Author GWASSocial IsolationGenetic EpidemiologyLubben Social Network ScaleTohoku Medical Megabank OrganizationSocial EpidemiologyHeritability

Genome-wide association study of social isolation in 63,497 Japanese individuals from the general population

Ohseto H; Inoue K; Takahashi I; Obara T; Narita A; Ishikuro M; Orui M; Murakami K; Noda A; Shinoda G; Takase M; Nakaya N; Kogure M; Hatanaka R; Nakaya K; Chiba I; Tokioka S; Kotozaki Y; Shimizu A; Tanno K; Hozawa A; Tamiya G; Kondo N; Kuriyama S

Translational Psychiatry, 2026

PubMed DOI
Co-Author GWASTohoku Medical Megabank OrganizationGenetic EpidemiologyBrain Imaging Analysis

Genome-wide Association Study of Subcortical Brain Structures in Japanese Ancestry: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study

Shinoda G; Ohseto H; Obara T; Orui M; Murakami K; Ishikuro M; Noda A; Nakaya N; Kogure M; Nakaya K; Hatanaka R; Chiba I; Takase M; Narita A; Kyosaka T; Mugikura S; Mori N; Fuse N; Hozawa A; Suzuki K; Kuriyama S

Research Square, 2026

Co-Author Wearable Devices

Calculation of approximate heart rate variability indicators based on low-resolution heart rate data provided by widely used commercially available wearable devices

Li X; Onoguchi G; Komatsu H; Ono C; Warita N; Yu Z; Nagaoka A; Horikoshi S; Iwabuchi K; Fuji K; Hino M; Takahashi Y; Ohseto H; Kobayashi N; Kikuchi S; Kunii Y; Obara T; Kuriyama S; Homma N; Nachev P; Ito A; Tomita H

Biomedical signal processing and control, 2026

DOI

2025

17
First Author PreeclampsiaPerinatal PeriodPlacentaTohoku Medical Megabank Organization

The relationship between preeclampsia subtypes and birth weight to placental weight ratio: Insights from a study of 17,709 pregnant Japanese women

Ohseto H; Ishikuro M; Shinoda G; Noda A; Murakami K; Orui M; Iwama N; Kikuya M; Metoki H; Hozawa A; Obara T; Kuriyama S

Placenta, 2025

DOI
First Author PreeclampsiaPerinatal PeriodTohoku Medical Megabank OrganizationResidential GreennessUrbanization and HealthEnvironmental Epidemiology

Association Between Residential Greenness and Preeclampsia in Japan: The TMM BirThree Cohort Study

Ohseto H; Uematsu A; Ishikuro M; Zheng X; Takahashi Y; Orui M; Murakami K; Noda A; Shinoda G; Chen G; Iwama N; Kikuya M; Metoki H; Hozawa A; Obara T; Nakaya T; Kuriyama S

medRxiv: the preprint server for health sciences, 2025

DOI
Co-Author Genetic EpidemiologyGWASTohoku Medical Megabank OrganizationHyperuricaemia

Genetic risk, lifestyle adherence, and risk of developing hyperuricaemia in a Japanese population

Takase M; Nakaya N; Nakamura T; Kogure M; Hatanaka R; Nakaya K; Chiba I; Tokioka S; Kanno I; Nochioka K; Tsuchiya N; Hirata T; Narita A; Obara T; Ishikuro M; Ohseto H; Uruno A; Kobayashi T; Kodama EN; Hamanaka Y; Orui M; Ogishima S; Nagaie S; Fuse N; Sugawara J; Kuriyama S; Matsuda K; Izumi Y; Kinoshita K; Tamiya G; Hozawa A; Yamamoto M; To MI

Rheumatology (Oxford, England), 2025

PubMed DOI
First Author GWASGenetic EpidemiologyAutism Spectrum DisorderClustering Analysis

Deep-embedded clustering by relevant scales and genome-wide association study in autism

Ueno F; Takahashi I; Ohseto H; Onuma T; Narita A; Obara T; Ishikuro M; Murakami K; Noda A; Matsuzaki F; Metoki H; Tamiya G; Kure S; Kuriyama S

PloS one, 2025

PubMed DOI
Co-Author GWASGenetic EpidemiologyPerinatal PeriodTohoku Medical Megabank OrganizationGestational Diabetes Mellitus

Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women

Kawahara T; Nawa N; Murakami K; Tanaka T; Ohseto H; Takahashi I; Narita A; Obara T; Ishikuro M; Orui M; Noda A; Shinoda G; Nagata Y; Nagaie S; Ogishima S; Sugawara J; Kure S; Kinoshita K; Hozawa A; Fuse N; Tamiya G; Bennett WL; Taub MA; Surkan PJ; Kuriyama S; Fujiwara T

Journal of human genetics, 2025

DOI
Co-Author Gestational Diabetes MellitusPerinatal PeriodTohoku Medical Megabank OrganizationChild Developmental DelayBlood Glucose

Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children

Kawaguchi C; Ishikuro M; Saito R; Murakami K; Noda A; Shinoda G; Aizawa M; Ohseto H; Iwama N; Orui M; Obara T; Kuriyama S

The journal of clinical endocrinology and metabolism, 2025

PubMed DOI
Co-Author Genetic EpidemiologyTohoku Medical Megabank OrganizationPolygenic Risk ScoreRenal FunctionGene-Environment Interaction

Effect of healthy lifestyle on renal dysfunction risk: interactions with genetic risk

Takase M; Nakaya N; Kogure M; Hatanaka R; Nakaya K; Chiba I; Tokioka S; Nochioka K; Nakamura T; Tsuchiya N; Hirata T; Kanno I; Narita A; Obara T; Ishikuro M; Ohseto H; Takahashi I; Uruno A; Kobayashi T; Kodama EN; Hamanaka Y; Orui M; Ogishima S; Nagaie S; Fuse N; Sugawara J; Kuriyama S; Matsuda K; Izumi Y; Kinoshita K; Tamiya G; Hozawa A; Yamamoto M

Clinical kidney journal, 2025

PubMed DOI
Co-Author Tohoku Medical Megabank OrganizationPerinatal PeriodObesityCase-Control StudyBreastfeeding

Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case–Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Sawane K; Takahashi I; Ishikuro M; Takumi H; Orui M; Noda A; Shinoda G; Ohseto H; Onuma T; Ueno F; Murakami K; Higuchi N; Tanaka T; Furuyashiki T; Nakamura T; Koshiba S; Ohneda K; Kumada K; Ogishima S; Hozawa A; Sugawara J; Kuriyama S; Obara T

The journal of nutrition, 2025

DOI
Co-Author GWASGenetic EpidemiologyTohoku Medical Megabank OrganizationCognitive Function

Genome-wide association study of cognitive function in population-based cohorts in japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study

Shinoda G; Obara T; Takahashi I; Ohseto H; Kawaguchi C; Narita A; Noda A; Murakami K; Orui M; Ishikuro M; Taira M; Sakamoto H; Nakaya N; Hozawa A; Fuse N; Tamiya G; Mugikura S; Suzuki K; Kuriyama S

Genes, brain, and behavior, 2025

PubMed DOI
Co-Author PregnancyHypertensionChild Health

Child developmental patterns by age 4 years across subtypes of hypertensive disorders of pregnancy

Chen G; Ishikuro M; Ohseto H; Noda A; Shinoda G; Orui M; Obara T; Kuriyama S

JAMA Network Open, 2025

PubMed DOI
Co-Author BreastfeedingCase-Control StudyObesityTohoku Medical Megabank OrganizationPerinatal PeriodLipidomics

Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study

Sawane K; Takahashi I; Ishikuro M; Takumi H; Orui M; Noda A; Shinoda G; Ohseto H; Onuma T; Ueno F; Murakami K; Higuchi N; Furuyashiki T; Nakamura T; Koshiba S; Ohneda K; Kumada K; Ogishima S; Hozawa A; Sugawara J; Kuriyama S; Obara T

Nutrition (Burbank, Los Angeles County, Calif.), 2025

PubMed DOI
Co-Author Polygenic Risk ScoreRisk PredictionGenetic EpidemiologyEpilepsySystematic Review and Meta-Analysis

Predictive value of the polygenic risk score for developing epilepsy: a systematic review and meta-analysis

Kubota T; Ngadimon IW; Ohseto H; Viswanathan S; Ravat P; Acharya MK; Kuroda N; Konomatsu K; Obara T; Jin K; Aoki M; Nakasato N

Epilepsy & behavior: E&B, 2025

PubMed DOI
Co-Author Polygenic Risk ScoreGenetic EpidemiologyGene-Environment InteractionRisk PredictionTohoku Medical Megabank OrganizationHypertensionFamily HistoryLifestyle Risk Factors

Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension

Takase M; Hirata T; Nakaya N; Kogure M; Hatanaka R; Nakaya K; Chiba I; Tokioka S; Nochioka K; Nakamura T; Tsuchiya N; Metoki H; Satoh M; Narita A; Obara T; Ishikuro M; Ohseto H; Takahashi I; Kobayashi T; Kodama EN; Hamanaka Y; Orui M; Ogishima S; Nagaie S; Fuse N; Sugawara J; Kuriyama S; Tamiya G; Hozawa A; Yamamoto M

Hypertension Research, 2025

PubMed DOI
First Author Perinatal PeriodSocial IsolationPreeclampsiaGestational Diabetes MellitusTohoku Medical Megabank OrganizationLubben Social Network ScaleLife's Essential 8Cardiovascular HealthAdverse Pregnancy OutcomesPreterm Birth

Synergistic effects of cardiovascular health and social isolation on adverse pregnancy outcomes

Ohseto H; Ishikuro M; Chen G; Takahashi I; Shinoda G; Noda A; Murakami K; Orui M; Iwama N; Kikuya M; Metoki H; Hozawa A; Obara T; Kuriyama S

Scientific reports, 2025

PubMed DOI
Co-Author Polygenic Risk ScoreGenetic EpidemiologyBlood GlucoseRisk PredictionTohoku Medical Megabank OrganizationCausal InferenceType 2 Diabetes MellitusMetabolomicsMediation Analysis

Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study

Takase M; Nakaya N; Kogure M; Hatanaka R; Nakaya K; Chiba I; Tokioka S; Nochioka K; Nakamura T; Tsuchiya N; Hirata T; Koshiba S; Kumada K; Motoike I; Hishinuma E; Narita A; Obara T; Ishikuro M; Ohseto H; Takahashi I; Kobayashi T; Kodama EN; Hamanaka Y; Orui M; Ogishima S; Nagaie S; Fuse N; Sugawara J; Kuriyama S; Matsuda K; Izumi Y; Ohneda K; Kinoshita K; Hozawa A; Yamamoto M; Biobank Japan Project; ToMMo investigators

Cardiovascular diabetology, 2025

PubMed DOI
Co-Author Gestational Diabetes MellitusSocial EpidemiologyTohoku Medical Megabank OrganizationEffect Modification

Household income modifies the association between social capital and gestational diabetes mellitus in Japan: Results from TMM BirThree Cohort Study

Sakakibara K; Kawahara T; Nawa N; Murakami K; Ohseto H; Takahashi I; Narita A; Obara T; Ishikuro M; Orui M; Noda A; Shinoda G; Nagaie S; Ogishima S; Sugawara J; Kure S; Kinoshita K; Hozawa A; Fuse N; Tamiya G; Bennett WL; Kuriyama S; Fujiwara T; Surkan PJ

Journal of diabetes investigation, 2025

PubMed DOI
First Author PreeclampsiaPolygenic Risk ScoreRisk PredictionGenetic EpidemiologyTohoku Medical Megabank OrganizationPerinatal PeriodLDpred2

Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study

Ohseto H; Ishikuro M; Obara T; Narita A; Takahashi I; Shinoda G; Noda A; Murakami K; Orui M; Iwama N; Kikuya M; Metoki H; Sugawara J; Tamiya G; Kuriyama S

Scientific reports, 2025

PubMed DOI

2024

7
Co-Author GWASGenetic EpidemiologyTohoku Medical Megabank OrganizationPostpartum DepressionEdinburgh Postnatal Depression Scale

Identification of risk loci for postpartum depression in a genome-wide association study

Li X; Takahashi N; Narita A; Nakamura Y; Sakurai-Yageta M; Murakami K; Ishikuro M; Obara T; Kikuya M; Ueno F; Metoki H; Ohseto H; Takahashi I; Nakamura T; Warita N; Shoji T; Yu Z; Ono C; Kobayashi N; Kikuchi S; Matsuki T; Nagami F; Ogishima S; Sugawara J; Hoshiai T; Saito M; Fuse N; Kinoshita K; Yamamoto M; Yaegashi N; Ozaki N; Tamiya G; Kuriyama S; Tomita H

Psychiatry and clinical neurosciences, 2024

PubMed DOI
Co-Author Tohoku Medical Megabank OrganizationFood Frequency QuestionnaireQuestionnaire Validation Study

Validity of a self-administered food frequency questionnaire for genomic and omics research among pregnant women: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Murakami K; Nakadate M; Obara T; Aizawa M; Takahashi I; Ishikuro M; Noda A; Ohseto H; Iwama N; Saito M; Takachi R; Sugawara S; Yonezawa Y; Yamashita T; Suzuki S; Ishihara J; Yamamoto M; Kuriyama S

Journal of epidemiology, 2024

PubMed DOI
Co-Author LifestyleHypertension

Associations of combined genetic and lifestyle risks with hypertension and home hypertension

Takase M; Hirata T; Nakaya N; Nakamura T; Kogure M; Hatanaka R; Nakaya K; Chiba I; Kanno I; Nochioka K; Tsuchiya N; Narita A; Metoki H; Satoh M; Obara T; Ishikuro M; Ohseto H; Uruno A; Kobayashi T; Kodama EN; Hamanaka Y; Orui M; Ogishima S; Nagaie S; Fuse N; Sugawara J; Kuriyama S; Tamiya G; Hozawa A; Yamamoto M; To MI

Hypertension research: official journal of the Japanese Society of Hypertension, 2024

PubMed DOI
Co-Author HypertensionPregnancyChild Health

Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Chen G; Ishikuro M; Ohseto H; Murakami K; Noda A; Shinoda G; Orui M; Obara T; Kuriyama S

Acta obstetricia et gynecologica Scandinavica, 2024

PubMed DOI
First Author Mental HealthPregnancy

Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory

Ohseto H; Takahashi I; Narita A; Obara T; Ishikuro M; Kobayashi N; Kikuchi S; Li X; Noda A; Murakami K; Tamiya G; Sugawara J; Tomita H; Kuriyama S

Depression and anxiety, 2024

PubMed DOI
Co-Author GWASPregnancy

Genome-wide association study of nausea and vomiting during pregnancy in Japan: the TMM BirThree Cohort Study

Yonezawa Y; Takahashi I; Ohseto H; Ueno F; Onuma T; Noda A; Murakami K; Ishikuro M; Obara T; Kuriyama S

BMC pregnancy and childbirth, 2024

PubMed DOI
Co-Author Tohoku Medical Megabank OrganizationClustering AnalysisGWASGenetic EpidemiologyObesity

Genome-wide association study based on clustering by obesity-related variables uncovers a genetic architecture of obesity in the Japanese and the UK populations

Takahashi I; Ohseto H; Ueno F; Oonuma T; Narita A; Obara T; Ishikuro M; Murakami K; Noda A; Hozawa A; Sugawara J; Tamiya G; Kuriyama S

Heliyon, 2024

PubMed DOI

2023

3
First Author

Ictal chest discomfort in a patient with temporal lobe seizures and amygdala enlargement

Ohseto H; Soga T; Kakisaka Y; Jin K; Ukishiro K; Konomatsu K; Kubota T; Fujimori J; Nakasato N

Epilepsy & behavior reports, 2023

PubMed DOI
First Author NutritionHypertensionPregnancy

Dietary calcium intake was related to the onset of pre-eclampsia: The TMM BirThree Cohort Study

Ohseto H; Ishikuro M; Obara T; Murakami K; Onuma T; Noda A; Takahashi I; Matsuzaki F; Ueno F; Iwama N; Kikuya M; Metoki H; Sugawara J; Kuriyama S

Journal of clinical hypertension (Greenwich, Conn.), 2023

PubMed DOI
Co-Author NutritionPregnancyChild Health

Association between frequency of breakfast intake before and during pregnancy and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Aizawa M; Murakami K; Takahashi I; Ohseto H; Noda A; Shinoda G; Orui M; Ishikuro M; Obara T; Hamada H; Iwama N; Saito M; Sugawara J; Kuriyama S

Nutrition journal, 2023

PubMed DOI

2022

2
First Author

The depressive state of the COVID-19-free general medical patients before and during the outbreak

Ohseto H; M, A; Yamaguchi T; Takayama S; Akaishi T; Kanno T; Onodera K; Ohsawa M; Tanaka J; Numata T; Tadano Y; Suzuki S; Ishizawa K; Kikuchi A; Arita R; Saito N; Ono R; Ishii T

J Hosp Gen Med, 2022

DOI
First Author

Preeclampsia prediction model using the dipstick test for proteinuria during early gestation

Ohseto H; Ishikuro M; Obara T; Murakami K; Onuma T; Noda A; Ueno F; Iwama N; Kikuya M; Metoki H; Sugawara J; Kuriyama S

Hypertension research in pregnancy, 2022

DOI

2020

1
Co-Author Clustering AnalysisCase-Control StudyGWASGenetic EpidemiologyAutism Spectrum DisorderSimons Simplex Collection

Clustering by phenotype and genome-wide association study in autism

Narita A; Nagai M; Mizuno S; Ogishima S; Tamiya G; Ueki M; Sakurai R; Makino S; Obara T; Ishikuro M; Yamanaka C; Matsubara H; Kuniyoshi Y; Murakami K; Ueno F; Noda A; Kobayashi T; Kobayashi M; Usuzaki T; Ohseto H; Hozawa A; Kikuya M; Metoki H; Kure S; Kuriyama S

Translational psychiatry, 2020

PubMed DOI

2018

1
First Author Metabolic SyndromePersonality TraitsEysenck Personality QuestionnaireKakegawa Cohort

Relationships among personality traits, metabolic syndrome, and metabolic syndrome scores: The Kakegawa cohort study

Ohseto H; Ishikuro M; Kikuya M; Obara T; Igarashi Y; Takahashi S; Kikuchi D; Shigihara M; Yamanaka C; Miyashita M; Mizuno S; Nagai M; Matsubara H; Sato Y; Metoki H; Tachibana H; Maeda-Yamamoto M; Kuriyama S

Journal of psychosomatic research, 2018

PubMed DOI
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